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They damage any proteins they come into contact with and the accumulation or build-up of these radicals and the damage they create causes oxidation (modifications to your proteins, lipids and DNA.) [1] An example of how free radicals could harm skin cells is a condition called idiopathic guttatehypomelanosis

Clore JN, Stillman J, Sugerman H

Studies have shown that levothyroxine treatment is not associated with clinically significant weight loss: Boston University Medical Center researchers found that only about half of hypothyroid patients lost weight after their hypothyroidism was treated

Less often, it may be caused by a chronic bacterial or fungal infection