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These physical means can be through the use of laser, microneedle, ultrasound, electroporation, magnetophoresis, or sonophoresis [3]

89 As BH 4 is very susceptible to oxidation, ONOO , resulting from the reaction of NO with superoxide anion, may oxidize BH 4 to the BH 3 radical and, thus, the resulting decrease in endothelial BH 4 can induce eNOS uncoupling