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Numerous aberrant ALS associated proteins can directly interact with mitochondria, compromising their functioning, for instance mutant SOD1 protein accumulates inside mitochondria and impairs energy-generating complexes

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Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not