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It can, depending on the medication and the dog's detoxification capacity

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Getting magnesium through food sources such as spinach and other leafy greens, legumes, nuts, and whole grains doesnt cause these side effects, though, says the Office of Dietary Supplements

This temporal dimension is relevant because early aversive suppression and later motivational downregulation are unlikely to be mechanistically identical, even when both are expressed clinically as reduced interest in food