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Overall, GLP-1s remain safe and effective medications

Complications of diabetes: complex pathophysiological changes Diabetes, as a chronic metabolic disease, starts with hyperglycemia and induces complex pathophysiological changes in the body, including hyperglycemia stress, mitochondrial dysfunction and ER stress.These factors influence each other to form a complex network of cellular and molecular signals (Fig

It has also been observed that patients taking GLP-1 or GLP/GIP medications are at risk of losing lean muscle mass during weight loss, so it is important for patients to maintain adequate sources of protein in their diets

Though most of these side effects do reduce once you have been taking the medication for a while, some side effects may persist or be intolerable