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To view a copy of this licence, visit About this article Cite this article Li, B., Chen, G., Zhong, H

Certain types of cancer, including renal cell carcinoma, hematologic malignancies, glioblastoma, pancreatic cancer, and those reported to depend on HIF-2, seem to depend on glutamine

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While mitochondria have their own antioxidant defenses, including mitochondrial SOD, these defenses are often insufficient to neutralize the high levels of ROS produced during oxidative phosphorylation, especially if mitochondrial function is compromised