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Tesamorelin, a stabilized analog of growth hormone-releasing hormone (GHRH), and Ipamorelin, a highly selective ghrelin mimetic, work in tandem to explore the "dual-pathway" stimulation of the pituitary gland

Small clinical trials using 500 mg of oral glutathione daily have shown modest reductions in melanin index, mainly in sun-exposed skin, though results are inconsistent across studies