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In experimental autoimmune encephalomyelitis (EAE) models, MCC950 effectively suppresses microglial activation and Th17 cell differentiation, consequently attenuating disease progression [384]

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These findings suggest that baseline dapagliflozin use was associated with attenuation of GLP-1 RA-associated HRV decline, particularly for indices reflecting overall variability, although this observation should be interpreted cautiously given the observational nature of the study