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Major US medical organizations including ACOG, The Menopause Society, and NASEM have concluded that compounded bioidentical hormone therapy claims of superior safety or effectiveness over FDA-approved hormone therapy are not substantiated by evidence from well-designed clinical studies, and that FDA-approved hormone therapy products are generally recommended over compounded alternatives when an FDA-approved formulation appropriate to the patient is available

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Evidence that trimethyllysine hydroxylase catalyzes the formation of (2 S ,3 S )-3-hydroxy- N -trimethyllysine