Dosing and Administration# Liraglutide# Saxenda (obesity) : Start 0.6 mg daily, titrate weekly by 0.6 mg to 3.0 mg daily (5-week titration) Victoza (T2D) : Start 0.6 mg daily, increase to 1.2 mg, max 1.8 mg daily Subcutaneous injection, abdomen/thigh/upper arm Any time of day, with or without food No oral weight management formulation Semaglutide# Wegovy (obesity) : Start 0.25 mg weekly, titrate monthly to 2.4 mg weekly (16-week titration) Ozempic (T2D) : Start 0.25 mg weekly, titrate to 0.5 mg, max 2.0 mg weekly Rybelsus (T2D) : 3 mg daily oral for 30 days, then 7 mg, max 14 mg Oral semaglutide 25 mg (approved 2025): Oral formulation for weight management Weekly injection or daily oral tablet
Retatrutide vs Tirzepatide vs Semaglutide: a head-to-head scientific comparison 2026 Retatrutide vs tirzepatide vs semaglutide Three generations, three mechanisms, three weight loss curves
Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work
Regular Exercise : Aim for at least 150 minutes of moderate-intensity exercise per week, such as brisk walking, swimming, or cycling
