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Free radical effects are mediated through lipid peroxidation, structural and functional alterations in proteins and deoxyribonucleic acid (DNA), and begin a cascade of progressive reactions to generate free radicals further, which ultimately affect cell membrane permeability and electrophysiological signaling, bring about apoptosis, altered gene expression, diminished gonadotrophins and anti-steroidogenic action, and inhibited production of protein adenosine triphosphate (ATP) and hence eventual damage of tissue

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