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10.1007/s00213-008-1204-x 45 Gonzalez-ReyE.PedrenoM.Delgado-MarotoV.Souza-MoreiraL.DelgadoM

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However, the emerging concept of the bone-brain axis has challenged this traditional view ( Leptin, a hypothalamic neuropeptide primarily secreted by adipocytes ( -aminobutyric acid (GABA), calcitonin gene-related peptide (CGRP), growth hormone releasing peptide (GHRP), corticotropin-releasing factor (CRF), and CART ( Interestingly, bone also can produce regulatory factors that influence neural activity ( AAs research advances, additional bone-derived proteins with neuroregulatory functions are being identified

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