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For the survival experiment, mice were checked daily and were culled when they showed visible distress symptoms such as weight loss of 10% or more, ascites equivalent to full-term pregnancy, reduced or slow activity, pale feet, hunching, piloerection, closed eyes and isolation from cage mates
[48] In a 4 to 6 year trial where patients were randomized to receive finasteride 5 mg/day, doxazosin 4 or 8 mg/day, a combination of the two drugs, or placebo, four patients reported breast cancer as an adverse experience
Yes it layers into a standard routine after cleansing