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While the most advanced dual-agonist medications currently lead the market, Phase 2 clinical data reveals that Retatrutide achieves an unprecedented average weight loss of 24.2% over 48 weeks

As discussed below, inhibition of fatty acid synthase (FAS), the rate-limiting enzyme in de novo lipogenesis, decreases appetite and promotes weight loss

Steady-state GPX4/GSH system The metabolic state in DACI significantly affects the activity of the GPX4 antioxidant axis and the sensitivity of cells to ferroptosis