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For instance, in a model of APAP-induced liver injury, the protective antioxidant and anti-inflammatory effects of the bioflavonoid naringin are highly dependent on the upregulation of both CHAC2 and NRF2 ( Taken together, the literature indicates that while both CHAC1 and CHAC2 participate in related biological processes, their different structural and regulatory properties suggest complementary rather than redundant functions

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Methods Mol Biol 1817:157168