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Functional modifications, such as chloroquine, histidine, PEG, or PEI, have been incorporated into PLL to address these limitations

However, due to fundamental questions regarding how to safely restore estrogen signaling locally in skin wounds, there are currently no therapeutic strategies addressing estrogen deficiency in elderly chronic wounds

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Rutkowski et al., 2008), and ER stress has also been shown to directly activate inflammatory signaling cascades(Lebeaupin et al., 2018