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Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer

To investigate the depletion of O 2 within the cells, cancer cells in a 1% O 2 atmosphere were treated with Ru(II)-OH, NP2, or NP4, and the O 2 concentration was assessed using the hypoxia probe pimonidazole hydrochloride

Role of interfacial hydrophobic residues in the stabilization of the leucine zipper structures of the transcription factors c-Fos and c-Jun