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Given reports about potential instability for this model 15 , we initially examined the effects of different morphine doses (3 mg/kg, 6 mg/kg, and 10 mg/kg) on constipation (Fig

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29 (2), 268272 (2008) S

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PEER REVIEW The peer review history for this article is available at Supporting information ACKNOWLEDGEMENTS The authors would also like to acknowledge Caroline Spencer (Rx Communications, Mould, UK) for medical writing assistance with the preparation of this manuscript, funded by Eli Lilly and Company

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