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Furthermore, CKD treatment has come a long way in the last few decades

6 Therapeutic strategies Given the complex pathophysiology and temporal dynamics of BBB disruption, effective treatment requires a phase-specific, multi-targeted approach

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Remarkably, 5-cholesten-3-one, derived by oxidation of the 3-hydroxyl group of cholesterol, is not a substrate in spite of a structure of the A and B rings identical to that in 5-AD and 5-PD, in which the double bond isomerization occurs (Figure 2)