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Thus, while IN chelation is promising for directly targeting the brain and CNS, it still requires careful consideration of formulation strategies (e.g., nanoparticle targeting or controlled-release systems) to improve site specificity, especially for drugs with a narrow therapeutic window

Most data come from small open-label studies, case reports, or clinic experience rather than large placebo-controlled trials

All handling should be conducted by qualified researchers in accordance with applicable regulations

Lifestyle changes such as adopting a balanced diet, increasing physical activity, and incorporating healthy habits are essential for long-term weight management