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SNO of this protein leads to its phosphorylation at Ser616, and thus, activation of fission in hippocampal neurons [318]

Beneficial effects of GLP-1 in reducing toxic protein accumulation are hypothesized to occur through the PI3K/Akt inactivation of glycogen synthase kinase 3 beta (GSK3) [82] and a possible GLP-1 mediated upregulation of IDE [83]