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Once a peptide is reconstituted, it is subject to: Hydrolysis Oxidation Structural changes over time These processes occur regardless of the solvent used

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The stimulation of this pathway leads to gut responses, including control of intestinal transit time and motility (i.e., delayed gastric emptying) (Forster et al., 1990), absorption rate and exposure of enteroendocrine cells (EECs) to nutrients, with changes in gastrointestinal hormones and pancreatic secretion, involved in satiety (Li and Owyang, 1994