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In contrast to the SUSTAIN-7 trial, which demonstrated superior HbA1c reduction with semaglutide compared to dulaglutide in patients receiving background metformin therapy [16], glycemic improvement in our cohort was more similar between groups

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When processed in KEGG for bioinformatic surveillance, this dataset provided additional evidence of a marked metabolic shift associated with GLP-1 agonist treatment, with a fold enrichment of 28.4 affecting the oxidative phosphorylation pathway, representing the presence of 12 significantly downregulated genes relevant to the progression of substrates through this pathway

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