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Autograft is a "gold standard" for clinical treatment due to its excellent osteogenesis, osteoinduction, and osteoconduction [86], but this method is limited by the amount of bone supplied at the site of extraction and causes additional damage to the bone area of the donor

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View Study [5]"Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris" Lu Z, Liu N, et al., 2023 Finding: Purified LR3 IGF-1 displayed excellent bioactivity for cell proliferation comparable to standard IGF-1, confirming that the molecular modifications preserve its biological function while extending its active lifespan