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N -terminal glutamic acid and glutamine residues can spontaneously cyclize to become pyroglutamate, or enzymatically converted by glutaminyl cyclases

Preclinical and clinical advances The translation of hydrogel-assisted brachytherapy from conceptual innovation to clinical practice requires rigorous preclinical validation and carefully designed early-phase clinical evaluation to establish safety, mechanism, and histology-specific efficacy [176]

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Due to its natural dual-layer formula (oil + jelly), slight variations in the layers may occur during shipping or storage