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The RRM2 overexpression cell line ( RRM2 -OE) was successfully constructed by transfecting TPC-1 and IHH4 cells with MOI = 15 using lentiviral LV18 (CMV/Puro) system

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Notably, OsDHAR was found to be a monomer under both reducing and oxidizing (10 mM H 2 O 2 ) conditions (Supplemental Fig

Early skepticism toward GLP-1 receptor agonists centered on gastrointestinal intolerance, concerns about pancreatitis, and the perception that widespread receptor expression would lead to unacceptable off-target effects