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1987 Jul;60(5):401-2. [PMID: 3662815]

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A portion of the drug can be metabolized as it is being absorbed across the intestinal wall

For example, chondrocytes isolated from OA cartilage displayed significant senescence levels, and ABT263 treatment reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in OA chondrocytes ( Next, we tested the potential of FOXO4-DRI in removing senescent chondrocytes, which has not been reported before