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And that increase stems from just one medication, highlighting the outsized impact GLP-1s can have on overall health care costs

A 2023 review in the American Journal of Clinical Nutrition noted that most probiotic weight loss claims lack rigorous randomized controlled trial support and that bacterial strain viability, gut transit time, and individual genetic factors all confound outcomes

Unlike many traditional fat-loss compounds, it is being researched as a non-stimulant option, making it appealing for those who prefer a more balanced and controlled approach to metabolic support

Importantly, while GLP-1 inhibits glucagon release to reduce hepatic glucose output, GIP can stimulate glucagon secretion under certain conditions, such as low glucose states, which may represent an adaptive mechanism to maintain glucose supply during fasting or stress 3