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While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)

Proc Natl Acad Sci U S A 111:34903495 Priyadarshini E, Priyadarshini SS, Pradhan N (2019) Heavy metal resistance in algae and its application for metal nanoparticle synthesis

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This innovative identification method has brought new opportunities for the study of natural metabolites