The pattern recurs across every endpoint category: an intermediate biomarker moves in the right direction, but the hard outcome the biomarker is supposed to predict does not follow
Discuss with your clinician about adjusting your GLP-1 dosing schedule if constipation is severe Consider prescription medications for persistent constipation that doesnt respond to other measures When to seek medical advice Contact your healthcare provider if you experience: No bowel movement for more than 4-5 days Severe abdominal pain or distension Blood in the stool Constipation alternating with diarrhoea Unexplained weight loss or fatigue Constipation that doesnt improve with self-management strategies Long-term outlook For most patients, constipation either resolves as the body adjusts to GLP-1 therapy or can be effectively managed with dietary and lifestyle modifications
[3] Conversely, rapid administration IV has occasionally caused hypotension or fainting, possibly from vasovagal responses or histamine release
[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Santos P., Herrmann A.P., Benvenutti R., Noetzold G., Giongo F., Gama C.S., Piato A.L., Elisabetsky E