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The maintenance frequency approach offers middle ground where users completing intensive initial treatment (6-12 months daily) transition to reduced frequency (2-4 times weekly) maintaining copper supplementation at lower intensity and cost while avoiding complete discontinuation allowing some benefit decline

Acknowledgements The authors are thankful to the University of Agriculture, Faisalabad, Pakistan, and Neurobiology Research Group, Department of Cellular Biology, Genetics, Histology and Pharmacology, Faculty of Medicine, University of Valladolid (Spain) for their collaboration for their support

doi: 10.1007/s40263-024-01113-z 52

Nevertheless, the trials showed a good safety profile for short-term use