[24] Hypertrophy of the extraocular muscles, adipogenesis, and deposition of nonsulfated glycosaminoglycans and hyaluronate, causes expansion of the orbital fat and muscle compartments, which within the confines of the bony orbit may lead to dysthyroid optic neuropathy, increased intraocular pressures, proptosis, venous congestion leading to chemosis and periorbital edema, and progressive remodeling of the orbital walls
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(4) One research hypothesis suggests that as MGF increases, the amino acid sequence attached to the COOH terminal of MGF may become activated and promote cell proliferation in muscle stem cells
If you experience any swelling whilst taking a GLP-1 medication, consider these practical steps: Review all your medications with your pharmacist or GP, as some drugs (calcium channel blockers, NSAIDs, corticosteroids) are more likely to cause fluid retention Monitor your salt intake excessive dietary sodium can contribute to water retention Elevate your legs when sitting or lying down if you have ankle swelling Wear compression stockings if recommended by your healthcare provider (after DVT has been excluded and if appropriate for your circulation) Keep a symptom diary , noting when swelling occurs, its severity, and any associated symptoms Regular monitoring is essential for all patients on GLP-1 therapy
