According to FDA labeling, no clinically meaningful differences in tirzepatide pharmacokinetics have been observed across all levels of renal function, including severe renal impairment and end-stage renal disease
Semaglutide base is the active ingredient in FDA-approved products (Ozempic, Wegovy, Rybelsus)
The 3 groups were homogenous at the baseline because there were no significant differences for the following features: mean age, prevalence of diabetes, prevalence of cardiovascular risk factors (including at least 1 of the following: hypertension, hyperlipidemia, obesity, and smoking), mean IIEF-EF score, category of ED severity distribution, and percentage of yes responses to SEP question 3 (Table 1)
Objective testing such as gastric ultrasound can aid in selected cases but does not always exist or is not always accessible