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Most users report mild to moderate symptoms, especially during the first few weeks of treatment, which is consistent with experiences reported by Ro semaglutide users as well

To promote weight loss, semaglutide delays gastric emptying, increases satiety, decreases appetite and energy intake

From a pathophysiological perspective, my first thought is that this could reflect an indirect effect on peripheral nerve sensitivity, possibly related to: rapid shifts in glucoselipid metabolism, changes in nerve conduction due to electrolyte fluctuations, or even a centrally mediated effect, considering GLP-1 receptor expression in the CNS