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The review covers both the statistical significance and real-world implications for daily practice

L-Carnitine is a substance produced by the liver and kidneys which convert body fat into energy

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Over-the-counter remedies may be appropriate in some cases, but should only be used after discussion with a pharmacist or GP: Oral rehydration salts (such as Dioralyte) are recommended for diarrhoea-related fluid loss Loperamide may be considered for short-term management of loose stools, but must be avoided if you have a fever, blood or mucus in your stools, or if antibiotic-associated diarrhoea (including Clostridioides difficile ) is suspected seek pharmacist or GP advice first For constipation, macrogol-based laxatives (such as Movicol) are a reasonable first-line option in line with NICE CKS guidance on constipation in adults