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Historically, PAs were implicated in the etiology of schizophrenia because certain antipsychotic and antimalarial drugs contain structural components resembling spermidine and were associated with extrapyramidal symptoms and psychosis (84)

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Moreover, the relative presence of Prevotella strains was inversely associated with Th17 cells in the small intestine, while positively related to disease activity (Cosorich et al., 2017)