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Phenytoin is the antiepileptic drug most often implicated in acute liver failure

3.6 Melanogenesis reduction Ultraviolet radiation stimulates melanogenesis through activation of the microphthalmia-associated transcription factor (MITF)-regulated pathway, promoting tyrosinase (TYR)-dependent melanin synthesis in melanosomes to protect against DNA damage, while excessive production leads to hyperpigmentation disorders (Kim et al., 2021)