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Single-cell analysis of ICI-associated colitis patient samples found expansion of CTLA-4 + Treg cells and differentiation of CD8 Trm cells to cytotoxic effector cells (83)

Patients with neurological conditions such as Parkinson's disease, multiple system atrophy, or pure autonomic failure may have impaired autonomic function, increasing their susceptibility to orthostatic hypotension

Increased PPAR degradation inhibited downstream fatty acid metabolism, leading to renal lipid accumulation, disrupted energy metabolism, and impaired kidney function

The constant urge to add extra meals or snacks disappears, making dietary compliance much simpler