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Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages

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Model and physiological GSSR substrates are, for example, l-cysteine-glutathione disulfide (GSSCys) 9,10,11,12,13,14,15 , coenzyme A-glutathione disulfide 3,16 , as well as S -glutathionylated serum albumin 9,11,17,18,19,20 , sirtuin 21 , sulfiredoxin 22 , and peroxiredoxins 23,24,25,26,27,28,29

Normally, tau proteins exist in a microtubule-bound form, but in AD, tau proteins become hyperphosphorylated, forming NFTs (Samudra et al., 2023)