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Variability in cultivation conditions, extraction methods, and dosage protocols across studies also complicates direct comparison of results and standardization of health claims

This restraint is the point, not a footnote

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Nevertheless, cannabis is usually self-administered for its mood-altering properties, and has been described as an addictive, dependence-producing drug due to the production of euphoria, the presence of reversible psychological impairment, an abstinence syndrome, and tolerance