The pathway for compounded GLP-1s has not closed entirely: legitimate patient-specific 503A compounding, with individualized clinical documentation, at the four-prescription safe harbor ceiling, remains legally available for genuine edge cases such as documented allergies to branded product excipients
Novo Nordisk said that PIONEER TEENS is the first clinical trial of an oral GLP-1 in this age group, and could become an important new option for T2D patients of this age "who require glycaemic control beyond that provided by the current standard of care." There are also limitations with the current treatment options, as metformin is unable to achieve blood glucose control targets in approximately half of adolescents, while basal insulins can have side effects, including low and potentially dangerous blood glucose levels (hypoglycaemia) and weight gain
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Remarkably, the survival benefits of GLP-1RAs, as observed in CVOTs, typically manifest over a more extended period than what our Kaplan Meier curves suggest 15,33
