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Poleg tega GLP-1 zavira sproanje hormona glukagona iz trebune slinavke, kar zmanja proizvodnjo glukoze v jetrih

They are so highly reactive they can damage cellular components in the body

This conformational constraint simultaneously increases metabolic stability by reducing the accessible surface area for protease attack and shifts receptor subtype selectivity toward the centrally expressed MC3R and MC4R subtypes relative to the uncyclised linear peptide

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