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However, both can cause gastrointestinal side effects that may be additive, and dehydration from these effects could affect methotrexate clearance

An unhealthy gut undermines absorption, increases systemic inflammation, and disrupts hormone signaling

4.3.1.3 Creatine inhibits ferroptosis by regulating lipid metabolism and iron homeostasis Creatine (Cr), an arginine derivative produced by gut bacteria (notably Bifidobacterium pseudolongum ), is a metabolite that has been proven to effectively inhibit ferroptosis

For example, following a heart-healthy diet like the Mediterranean diet, which is rich in fruits, vegetables, whole grains, lean proteins, and healthy fats, can improve both blood sugar management and cardiovascular health