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In rodents and primates, hypothalamic IGF1 expression increases at puberty, which activates kisspeptin-GnRH neurons [3, 15]

Critical role for p53-serine 15 phosphorylation in stimulating transactivation at p53-responsive promoters

This oxidative burden is exacerbated by Ang II, which promotes mitochondrial fission via dynamin-related protein 1 (Drp1) and inhibits mitophagy, leading to the accumulation of damaged, ROS-producing mitochondria (Tbara et al., 2025)