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In Study 1 (NCT00554216), patients with obesity (BMI greater than or equal to 35 kg/m2) were randomized to receive 1 year of treatment with placebo (N=514), phentermine and topiramate extended-release 3.75 mg/23 mg (N=241), or phentermine and topiramate extended-release 15 mg/92 mg (N=512) in a 2:1:2 ratio

At the 12mg dose, participants achieved average weight loss of 24.2% from baseline

The structural diversity of these compounds is attributed to their biosynthetic origins, including organosulfur compounds from Allium species, glucosinolates from cruciferous vegetables, and other sulfur metabolites from microbial and marine sources