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Huberman noted this update in his podcast introduction just prior to the Koniver episodes release

This suggests that a resistance exercise-related mechanism of inducing plasma NO, perhaps due to increased shear stress that triggered an up-regulation in NO-cGMP signaling, is a conceivable candidate for this response

Unlike conventional hormones encoded in nuclear DNA, this peptide is transcribed from the mitochondrial genome and then released into the cytosol and nucleus under stress conditions