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This warning is not based on human epidemiology alone but largely originates from rodent toxicology studies , where GLP-1 receptor activation led to: Increased calcitonin secretion C-cell hyperplasia C-cell adenomas and carcinomas in rats/mice These findings have been consistently observed across multiple GLP-1 receptor agonists

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Pegloticase If other medications are not effective at lowering uric acid levels, pegloticase may be used as an alternate option