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Precedent: CagriSema Success Supports Combination Approach The strongest evidence supporting a cagrilintide blend with retatrutide comes from Novo Nordisk's CagriSema program, which combines cagrilintide with semaglutide (a GLP-1 receptor agonist)

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The authors said future research will explore how patient characteristics, specific medications, and timing of therapy influence treatment trajectories, with the goal of informing more personalized and sustainable approaches to obesity care