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A recent genome-wide association study showed that the key target tissues and cell types of kidney stones are mainly proximal renal tubules, and proximal renal tubular epithelial cells (pRTECs) injury further promotes kidney stone formation [98]

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In addition, studies in which weight loss was greater during treatment than in the control group and studies in which lifestyle interventions were continued observed significant weight gain after drug discontinuation

Because of this structural mimicry, gymnemic acids can bind to and block the sugar receptors in the intestines, helping to block the absorption of sugar into the bloodstream and blunting postprandial glucose spikes