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86 In cardiomyocytes, nicotine induced the same changes, with increased mitochondrial fission and decreased mitochondrial fusion, which not only induced excessive ROS, but also led to cell apoptosis due to excessive fission

In addition to its direct damaging effects, NE can enhance the activation of the immune response, contributing to a cytokine storm, a dangerous hyper-inflammatory condition seen in severe COVID-19 cases

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